Brostallicin
Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity.
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- No. CAS: 203258-38-2
- Fòrmula: C30H36BrClN12O5
- Peso molecular:760.04
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.64 nM
Compound: 17 (brostallicin)
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Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)
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[PMID: 15115402] |
| L1210 | IC50 |
1.8 nM
Compound: 9
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In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure
In vitro cytotoxicity against L1210 murine leukemia cells after 48 hr of continuous exposure
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[PMID: 12031321] |
| L1210 | IC50 |
1.85 nM
Compound: 17 (brostallicin)
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In vitro test for cytotoxicity against L1210 murine leukemia cells
In vitro test for cytotoxicity against L1210 murine leukemia cells
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[PMID: 15115402] |
| L1210 | IC50 |
2.13 nM
Compound: 17 (brostallicin)
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Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells
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[PMID: 15115402] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 203258-38-2
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Peso molecular 760.04
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Fòrmula C30H36BrClN12O5
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SMILES
O=C(C(Br)=C)NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCNC(N)=N)=O)=C4)=O)=C3)=O)=C2)=O)=C1.Cl
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Synonyms
PNU-166196
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brostallicin Related Classifications
HY-16117A Related Classifications
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