BTZO-1
Based on 2 publication(s) in Google Scholar
BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
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- Pureza: 99.32%
- No. CAS: 99420-15-2
- Fòrmula: C13H8N2OS
- Peso molecular:240.28
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Apoptosis Compound Library
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Publications Citing Use of MedChemExpress (MCE) BTZO-1
More
Actividad biológica
Kd:68.6 nM (Macrophage migration inhibitory factor)[1]
BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary Neonatal Rat Cardiomyocytes
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Concentration:0-330 nM
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Incubation Time:24 hours
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Result:Suppressed serum deprivation or DOX-induced cell death.
Chemical Information
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No. CAS 99420-15-2
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Appearance Solid
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Peso molecular 240.28
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Fòrmula C13H8N2OS
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Color White to off-white
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SMILES
O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C13
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
J Hazard Mater
Cooperative application of transcriptomics and ceRNA hypothesis: lncRNA-00742/miR-116 targets CD74 to mediate vanadium-induced mitochondrial apoptosis in duck liver. [Abstract]2024 Sep 18:480:135904. PMID: 39303616
Solvente y solubilidad
DMSO : 8.33 mg/mL (34.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1618 mL | 20.8091 mL | 41.6181 mL | 104.0453 mL |
| 5 mM | 0.8324 mL | 4.1618 mL | 8.3236 mL | 20.8091 mL | |
| 10 mM | 0.4162 mL | 2.0809 mL | 4.1618 mL | 10.4045 mL | |
| 15 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9364 mL | |
| 20 mM | 0.2081 mL | 1.0405 mL | 2.0809 mL | 5.2023 mL | |
| 25 mM | 0.1665 mL | 0.8324 mL | 1.6647 mL | 4.1618 mL | |
| 30 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4682 mL |
BTZO-1 Related Classifications
HY-110084 Related Classifications
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