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Referencia número: HY-184363

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C14-306

C14-306 is an ionizable lipid with a linear 306 amine core and a C14 alkyl tail. C14-306 enhances brain transfection efficiency. Lipid nanoparticles (LNP) formulated with C14-306 promote mRNA delivery, increase neuronal transfection rate, and facilitate Cre-mediated recombination in the brain, while reducing off-target expression in the liver.

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No. CAS: 2153563-36-9
Fòrmula: C₆₃H₁₃₁N₃O₄
Peso molecular:994.76

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

C14-306 Chemical Structure

No. CAS: 2153563-36-9

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
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Actividad biológica

Descripciòn

In Vitro

LNPs formulated with C14-306 (60 ng mRNA/20,000 cells; 24 h) efficiently and specifically transfect the neuronal cell line SH-SY5Y in vitro, exhibit extremely low transfection activity toward the brain microvascular endothelial cell line hCMEC/D3, and induce high uptake by neuronal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LNPs formulated with C14-306 (0.4 mg/kg encapsulated mRNA; i.v.; single dose) (linear amine core, C14 tail) facilitate significantly enhanced mRNA delivery to the healthy mouse brain compared to shorter-tailed counterparts with the same core^[1].
LNPs formulated with C14-306 (0.35 mg/kg encapsulated mRNA; i.v.; single dose), particularly LNP 14, drive potent, liver-sparing mRNA transfection in the healthy Mus musculus brain, with efficacy far exceeding FDA-approved and benchmark LNPs^[1].
The C14-306-containing LNP 14 (0.35 mg/kg encapsulated mRNA; i.v.; single dose) does not induce BBB leakage, significant systemic inflammation, or liver enzyme elevation in healthy mice, demonstrating a favorable safety profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2153563-36-9
Peso molecular 994.76
Fòrmula C₆₃H₁₃₁N₃O₄
SMILES

OC(CN(CCCN(C)CCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Han EL, et al. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS nano. 2026 Feb 03;20(4):3807-3820. [Content Brief]

[2]. Bhunia S M, Bhattacharjee A, Saha P, et al. Lipid Nanoparticles for Overcoming Biological Barriers to mRNA Delivery to the Brain[J].

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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