Cauloside A
Based on 1 Customer Validation
Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.75%
- No. CAS: 17184-21-3
- Fòrmula: C35H56O8
- Peso molecular:604.81
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Natural Product Library
HY-L021
-
Glycoside Compound Library
HY-L042
-
Antifungal Compound Library
HY-L048
-
Medicine Food Homology Compound Library
HY-L055
-
Terpenoids Library
HY-L056
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
Plant-Sourced Natural Product Library
HY-L115
-
Heterocyclic Compound Library
HY-L138
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
Miao Ethnicity Medicine Compound Library
HY-L190
-
Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
HY-L194
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library
HY-L209
-
Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
-
Mongolian Medicine Compound Library
HY-L238
-
Tonifying Traditional Chinese Medicine Monomer Compound Library
HY-L246
-
Mass Spectrometry Natural Product Library
HY-L262
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
29.71 μM
Compound: 10a
|
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| A549 | IC50 |
40 μM
Compound: 23
|
Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence
|
[PMID: 19200744] |
| A549 | IC50 |
58 μM
Compound: 23
|
Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test
|
[PMID: 19200744] |
| DLD-1 | IC50 |
54 μM
Compound: 23
|
Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence
|
[PMID: 19200744] |
| DLD-1 | IC50 |
57 μM
Compound: 23
|
Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test
|
[PMID: 19200744] |
| HeLa | IC50 |
27.67 μM
Compound: 10a
|
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| HepG2 | IC50 |
19.12 μM
Compound: 10a
|
Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| HL-60 | IC50 |
14.52 μM
Compound: 10a
|
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
| RAW264.7 | IC50 |
2.25 μM
Compound: 14
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay
|
[PMID: 31301930] |
| U-87MG ATCC | IC50 |
18.45 μM
Compound: 10a
|
Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay
|
[PMID: 23992864] |
Chemical Information
-
No. CAS 17184-21-3
-
Appearance Solid
-
Peso molecular 604.81
-
Fòrmula C35H56O8
-
Color White to off-white
-
SMILES
C[C@@]1(CC[C@@]2([H])[C@]3(C)CO)[C@@](CC=C([C@]4([H])CC5(C)C)[C@]1(CC[C@]4(CC5)C(O)=O)C)([H])[C@]2(CC[C@@H]3O[C@H](OC[C@@H]6O)[C@@H]([C@H]6O)O)C
-
Synonyms
Leontoside A
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (165.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Nam Hee Choi, et al. Antifungal activity of sterols and dipsacus saponins isolated from Dipsacus asper roots against phytopathogenic fungi. Pestic Biochem Physiol. 2017 Sep;141:103-108. [Content Brief]
[2]. Sandipan Datta, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014 Jan 24;77(1):111-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6534 mL | 8.2671 mL | 16.5341 mL | 41.3353 mL |
| 5 mM | 0.3307 mL | 1.6534 mL | 3.3068 mL | 8.2671 mL | |
| 10 mM | 0.1653 mL | 0.8267 mL | 1.6534 mL | 4.1335 mL | |
| 15 mM | 0.1102 mL | 0.5511 mL | 1.1023 mL | 2.7557 mL | |
| 20 mM | 0.0827 mL | 0.4134 mL | 0.8267 mL | 2.0668 mL | |
| 25 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.6534 mL | |
| 30 mM | 0.0551 mL | 0.2756 mL | 0.5511 mL | 1.3778 mL | |
| 40 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0334 mL | |
| 50 mM | 0.0331 mL | 0.1653 mL | 0.3307 mL | 0.8267 mL | |
| 60 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6889 mL | |
| 80 mM | 0.0207 mL | 0.1033 mL | 0.2067 mL | 0.5167 mL | |
| 100 mM | 0.0165 mL | 0.0827 mL | 0.1653 mL | 0.4134 mL |
Cauloside A Related Classifications
HY-N3557 Related Classifications
Powered by Bioz