Ceratamine A
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 634151-15-8
- Fòrmula: C17H16Br2N4O2
- Peso molecular:468.14
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
11.2 μM
Compound: Ceratamine A
|
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 29433924] |
| A549 | IC50 |
26.8 μM
Compound: Ceratamine A
|
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 29433924] |
| BGC-823 | IC50 |
20 μM
Compound: Ceratamine A
|
Cytotoxicity against human BGC823 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human BGC823 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 29433924] |
| HCT-116 | IC50 |
12.4 μM
Compound: Ceratamine A
|
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 29433924] |
| HepG2 | IC50 |
7.8 μM
Compound: Ceratamine A
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 29433924] |
| MCF7 | IC50 |
5 μg/mL
Compound: 1
|
Antimitotic activity in human MCF7mp53 cells assessed as induction of mitotic arrest after 20 hrs
Antimitotic activity in human MCF7mp53 cells assessed as induction of mitotic arrest after 20 hrs
|
[PMID: 20945907] |
Chemical Information
-
No. CAS 634151-15-8
-
Peso molecular 468.14
-
Fòrmula C17H16Br2N4O2
-
SMILES
O=C(N(C)C=C1)C(CC2=CC(Br)=C(OC)C(Br)=C2)=C3C1=NC(NC)=N3
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Manzo E, et al. Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea. Org Lett. 2003 Nov 27;5(24):4591-4. [Content Brief]
[2]. Nodwell M, et al. Synthetic approaches to the microtubule-stabilizing sponge alkaloid ceratamine A and desbromo analogues. J Org Chem. 2009 Feb 6;74(3):995-1006. [Content Brief]
[3]. Pan X, et al. Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A. Bioorg Med Chem Lett. 2018 Mar 1;28(5):866-868. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ceratamine A Related Classifications
HY-N6997 Related Classifications
Powered by Bioz