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Referencia número: HY-116473

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CFM-1

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells.

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No. CAS: 1380448-60-1
Fòrmula: C₁₂H₇BrN₂O₂S₂
Peso molecular:355.23

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CFM-1 Chemical Structure

No. CAS: 1380448-60-1

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Daoy	IC₅₀	8.12 μg/mL Compound: CFM-1	Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
HeLa	IC₅₀	13.5 μg/mL Compound: CFM-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
Huh-7	IC₅₀	8.18 μg/mL Compound: CFM-1	Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]
MDA-MB-231	IC₅₀	19.7 μg/mL Compound: CFM-1	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay	[PMID: 25555142]

Chemical Information

No. CAS 1380448-60-1
Peso molecular 355.23
Fòrmula C₁₂H₇BrN₂O₂S₂
SMILES

O=C1NC2=C(C=C(Br)C=C2C)/C1=C(SC(N3)=S)\C3=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286(44):38000-38017. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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