Clesrovimab
Based on 3 publication(s) in Google Scholar
Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection.
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- Pureza: 99.77%
- No. CAS: 2429913-18-6
- Peso molecular:146.75 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Clesrovimab
More
Actividad biológica
Human IgG1 kappa
Human
RSV-F
Clesrovimab potently neutralizes historical and contemporary RSV A and B isolates in Hep-2 cells, with median EC50 values of 25 pM, 30 pM, 121 pM, and 130 pM for historical RSV A, historical RSV B, contemporary RSV A, and contemporary RSV B isolates, respectively[1].
Clesrovimab selects for resistant variants during in vitro serial passage of RSV A and RSV B, with >3800-fold reduced susceptibility in RSV A variants and >360-fold reduced susceptibility in an RSV B variant[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
A0A0X8XRK2
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Fusion glycoprotein F0/F Protein, HRSV (sf9, His, HY-P75182) can bind Clesrovimab. The EC50 for this effect is 4.686 ng/mL.
Chemical Information
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No. CAS 2429913-18-6
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Appearance Liquid
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Peso molecular 146.75 kDa
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Color Colorless to light yellow
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SMILES
[Clesrovimab]
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Synonyms
MK1654
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Infect Dis
Respiratory Syncytial Virus Fusion Protein Epitope-specific Antibodies and Neutralizing Activities against Various Respiratory Syncytial Virus Strains. [Abstract]2025 Jul 18:jiaf375. PMID: 40675573 -
J Infect Dis
Amino acid substitutions in the fusion protein of respiratory syncytial virus in Fukushima, Japan during 2008-2023 and their effects. [Abstract]2024 Dec 24:jiae636. PMID: 39719011 -
Pureza y Documentación
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Ficha de datos (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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