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Referencia número: HY-18228

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CP-352664

CP-352664 is a JAK inhibitor. CP-352664 has a inhibitoinhibits JAK3 with an EC₅₀ value of 210 nM. CP-352664 is promising for research of organ transplant rejection and autoimmune disorders such as rheumatoid arthritis.

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No. CAS: 1097883-05-0
Fòrmula: C₁₈H₁₈N₄
Peso molecular:290.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

CP-352664 Chemical Structure

No. CAS: 1097883-05-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas JAK :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	10 μM Compound: CP-352664	Inhibition of fetal calf serum-induced proliferation of human foreskin fibroblast assessed as [3H]thymidine incorporation after 4 days by scintillation counting Inhibition of fetal calf serum-induced proliferation of human foreskin fibroblast assessed as [3H]thymidine incorporation after 4 days by scintillation counting	[PMID: 14593182]
Sf9	IC₅₀	210 nM Compound: 2a	Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
Sf9	IC₅₀	>10000 nM Compound: 2a	Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
T-cell	IC₅₀	3694 nM Compound: CP-352664	Inhibition of IL2-induced proliferation of human T cells assessed as [3H]thymidine incorporation after 72 hrs by scintillation counting Inhibition of IL2-induced proliferation of human T cells assessed as [3H]thymidine incorporation after 72 hrs by scintillation counting	[PMID: 14593182]
T-cell	IC₅₀	3200 nM Compound: 2a	Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay	[PMID: 21105711]

Chemical Information

No. CAS 1097883-05-0
Peso molecular 290.36
Fòrmula C₁₈H₁₈N₄
SMILES

C1(N2C3=C(C4C2CCCC4)C=CC=C3)=C5C=CNC5=NC=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Flanagan ME, et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem. 2010 Dec 23;53(24):8468-84. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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Chemical Information
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CP-352664

Ver todos los productos específicos de isoformas JAK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CP-352664 Related Classifications

HY-18228 Related Classifications