CP-775146
Based on 1 Customer Validation
CP-775146 is a selective PPARα agonist (Ki of 24.5 nM) that binds strongly to the PPARα ligand. CP-775146 has no observable affinity for PPARβ and PPARγ.CP-775146 shows hypolipidemic activity. CP-775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.70%
- No. CAS: 702680-17-9
- Fòrmula: C26H33NO4
- Peso molecular:423.54
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (4-week-old) with a high-fat diet (HFD)[2]
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Dosage:0.1 mg/kg, 0.3 mg/kg
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Administration:Intraperitoneal injection (i.p.); daily; for 3 days
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Result:Reduced the serum levels of liver enzymes, such as ALT and AST and lipid metabolism-related biomarkers, including TGs and LDL-c, non-HDL-c, and hepatic TG content, at a dosage of 0.1 mg/kg.
HFD-induced pathological liver changes improved.
The expression of genes involved in liver fatty acid oxidation (Acadl, Acox-1, CPT-1, and Ehhadh) was upregulated.
Induced the expression of thermogenesis genes (Cidea, Ucp1) and lipolysis genes (Hsl, Atgl).
Chemical Information
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No. CAS 702680-17-9
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Appearance Solid
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Peso molecular 423.54
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Fòrmula C26H33NO4
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Color White to off-white
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SMILES
CC(OC1=CC=CC([C@H]2CN(C(CC3=CC=C(C(C)C)C=C3)=O)CCC2)=C1)(C)C(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 42 mg/mL (99.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kane CD, et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb;75(2):296-306. [Content Brief]
[2]. Shengjie Tang, et al. The Effects of New Selective PPAR α Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. J Diabetes Res. 2020 May 4;2020:4179852. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3611 mL | 11.8053 mL | 23.6105 mL | 59.0263 mL |
| 5 mM | 0.4722 mL | 2.3611 mL | 4.7221 mL | 11.8053 mL | |
| 10 mM | 0.2361 mL | 1.1805 mL | 2.3611 mL | 5.9026 mL | |
| 15 mM | 0.1574 mL | 0.7870 mL | 1.5740 mL | 3.9351 mL | |
| 20 mM | 0.1181 mL | 0.5903 mL | 1.1805 mL | 2.9513 mL | |
| 25 mM | 0.0944 mL | 0.4722 mL | 0.9444 mL | 2.3611 mL | |
| 30 mM | 0.0787 mL | 0.3935 mL | 0.7870 mL | 1.9675 mL | |
| 40 mM | 0.0590 mL | 0.2951 mL | 0.5903 mL | 1.4757 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4722 mL | 1.1805 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3935 mL | 0.9838 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2951 mL | 0.7378 mL |
CP-775146 Related Classifications
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