CW0134
CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells.
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- No. CAS: 1076235-18-1
- Fòrmula: C11H7ClF3N3O2
- Peso molecular:305.64
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
282 nM
Compound: 8
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Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
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[PMID: 39005064] |
CW0134 (10 nM-10 μM) inhibits the expression of IL-2 (6 h) and viability (24 h) of Jurkat cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat
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Concentration:10 nM-10 μM
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Incubation Time:24 h
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Result:Inhibited cell viability of Jurkats.
Chemical Information
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No. CAS 1076235-18-1
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Peso molecular 305.64
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Fòrmula C11H7ClF3N3O2
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SMILES
ClC1=NC(NN2C(C=C(C)C2=O)=O)=CC=C1C(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CW0134 Related Classifications
HY-161391 Related Classifications
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