DDO-02005
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1186049-44-4
- Fòrmula: C21H27Cl2N3O2
- Peso molecular:424.36
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
IC50: 0.72 μM (Kv1.5 potassium channel)[1]
Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats[1].
| IV (1 mg/kg) | PO (1.25 mg/kg) | |
| t1/2 (h) | 3.23 ± 1.07 | 6.25 ± 2.40 |
| Cmax (μg/L) | 90.23 ± 28.83 | 1.27 ± 0.40 |
| AUC0-t (μg/L·h) | 178.42 ± 39.33 | 4.41 ± 0.69 |
| CL (L/h/kg) | 5.83 ± 1.44 | 36.51 ± 2.54 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1186049-44-4
-
Peso molecular 424.36
-
Fòrmula C21H27Cl2N3O2
-
SMILES
COC1=CC=C(C=C1)CNC2CCN(CC3=NC4=CC=CC=C4O3)CC2.[H]Cl.[H]Cl
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDO-02005 Related Classifications
HY-144801A Related Classifications
Powered by Bioz