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Referencia número: HY-169013

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DDO-3733

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates.

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No. CAS: 2923531-63-7
Fòrmula: C₁₀H₆F₂N₂OS
Peso molecular:240.23

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DDO-3733 Chemical Structure

No. CAS: 2923531-63-7

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	40.79 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM)	[PMID: 39145509]
SW-620	IC₅₀	54.41 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM)	[PMID: 39145509]

Chemical Information

No. CAS 2923531-63-7
Peso molecular 240.23
Fòrmula C₁₀H₆F₂N₂OS
SMILES

S=C(C1=CC2=C(F)C=C(F)C=C2OC1=N)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang Q, et al. Allosteric Activation of Protein Phosphatase 5 with Small Molecules. J Med Chem. 2024 Sep 12;67(17):15080-15097. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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