Dopexamine
Dopexamine is a β2 adrenergic receptor agonist.
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- No. CAS: 86197-47-9
- Fòrmula: C22H32N2O2
- Peso molecular:356.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
β2 adrenergic receptor[1]
Dopexamine is a dopamine analogue with agonist activity at β2 and dopaminergic receptors. Dopexamine can attenuate the systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow[1]. Dopexamine is a dopamine analog that stimulates β-adrenergic and dopamine 1 and 2 receptors, conferring some vasodilatory effects. Dopexamine reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics, either blood pressure or stroke volume[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 86197-47-9
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Peso molecular 356.50
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Fòrmula C22H32N2O2
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SMILES
OC1=C(O)C=CC(CCNCCCCCCNCCC2=CC=CC=C2)=C1
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Synonyms
FPL 60278
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Bangash MN, et al. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. Crit Care. 2013 Mar 28;17(2):R57. [Content Brief]
[2]. Hollenberg SM. Dopexamine: immunomodulatory, hemodynamic, or both? Crit Care. 2013 May 13;17(3):143. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dopexamine Related Classifications
HY-106562 Related Classifications
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