EAPB 02303
Based on 1 Customer Validation
EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.05%
- No. CAS: 1958290-51-1
- Fòrmula: C17H14N4O2
- Peso molecular:306.32
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2058 | IC50 |
4 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| A-375 | IC50 |
3 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| IPC-298 | IC50 |
40 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
| MeWo | IC50 |
3 nM
Compound: 9d; EAPB02303
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Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 33309473] |
Chemical Information
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No. CAS 1958290-51-1
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Appearance Solid
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Peso molecular 306.32
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Fòrmula C17H14N4O2
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Color Light yellow to yellow
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SMILES
OC(C=C1)=C(O)C=C1C2=CN=C3C(NC)=NC4=CC=CC=C4N32
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
H2O : 30 mg/mL (97.94 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2646 mL | 16.3228 mL | 32.6456 mL | 81.6140 mL |
| 5 mM | 0.6529 mL | 3.2646 mL | 6.5291 mL | 16.3228 mL | |
| 10 mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 8.1614 mL | |
| 15 mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 5.4409 mL | |
| 20 mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 4.0807 mL | |
| 25 mM | 0.1306 mL | 0.6529 mL | 1.3058 mL | 3.2646 mL | |
| 30 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
| 40 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL | |
| 60 mM | 0.0544 mL | 0.2720 mL | 0.5441 mL | 1.3602 mL | |
| 80 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
EAPB 02303 Related Classifications
HY-153384 Related Classifications
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