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Referencia número: HY-108814

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Ecallantide

(Synonyms: DX-88)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Ecallantide (DX-88) is a specific plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema.

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No. CAS: 460738-38-9
Fòrmula: C₃₀₅H₄₄₂N₈₈O₉₁S₈
Peso molecular:7053.81

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ecallantide Chemical Structure

No. CAS: 460738-38-9

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Actividad biológica

Descripciòn

Ecallantide (DX-88) is a specific plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema^[1].

Ver todos los productos específicos de isoformas Kallikrein :

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 460738-38-9
Peso molecular 7053.81
Fòrmula C₃₀₅H₄₄₂N₈₈O₉₁S₈
Synonyms

DX-88
Sequence

Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp (Disulfide bond:Cys1-Cys6, Cys2-Cys4, Cys3-Cys5)
Sequence Shortening

EAMHSFCAFKADDGPCRAAHPRWFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRD (Disulfide bond:Cys1-Cys6, Cys2-Cys4, Cys3-Cys5)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Pharmacol Res

Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential. [Abstract]

2024 Nov:209:107460. PMID: 39393436
Arch Toxicol

A novel polypeptide from stony coral Goniopora columna inhibits thrombosis by interfering with the contact-kinin pathway. [Abstract]

2025 Jun 4. PMID: 40464975

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Martello JL, et al. Ecallantide for treatment of acute attacks of hereditary angioedema. Am J Health Syst Pharm. 2012 Apr 15;69(8):651-7. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Ecallantide

2 Cited Publications

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Ecallantide

Publications Citing Use of MedChemExpress (MCE) Ecallantide

Ver todos los productos específicos de isoformas Kallikrein

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Ecallantide Related Classifications

HY-108814 Related Classifications