ER-67880
ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma.
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- No. CAS: 247186-96-5
- Fòrmula: C15H13ClN2O3S
- Peso molecular:336.79
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.37 μM
Compound: 5
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Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
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[PMID: 12383017] |
| HCT-116 | IC50 |
2.2 μM
Compound: 5
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Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
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[PMID: 12383017] |
| KB | IC50 |
0.55 μg/mL
Compound: 16
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Antiproliferative activity against KB human nasopharynx carcinoma in vitro
Antiproliferative activity against KB human nasopharynx carcinoma in vitro
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[PMID: 10508428] |
| KB | IC50 |
0.55 μg/mL
Compound: 3
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In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
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[PMID: 10866386] |
| MC-38 | IC50 |
0.2 μg/mL
Compound: 16
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In vitro antiproliferative activity against colon 38 murine adenocarcinoma
In vitro antiproliferative activity against colon 38 murine adenocarcinoma
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[PMID: 10508428] |
| MC-38 | IC50 |
0.2 μg/mL
Compound: 3
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In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
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[PMID: 10866386] |
| P388 | IC50 |
0.76 μg/mL
Compound: 16
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Antiproliferative activity against P388 murine leukemia in vitro
Antiproliferative activity against P388 murine leukemia in vitro
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[PMID: 10508428] |
| P388 | IC50 |
0.76 μg/mL
Compound: 3
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In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
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[PMID: 10866386] |
| P388 | IC50 |
1.2 μM
Compound: 5
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Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
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[PMID: 12383017] |
| P388 | IC50 |
1.2 μM
Compound: 5
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Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
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[PMID: 12383017] |
Chemical Information
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No. CAS 247186-96-5
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Peso molecular 336.79
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Fòrmula C15H13ClN2O3S
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SMILES
O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER-67880 Related Classifications
HY-118385 Related Classifications
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