EYE-002
EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C16H25NO5
- Peso molecular:311.37
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
EYE-002 (0.1-10 μM) inhibits RPE65 activity in bovine RPE microsomes with an IC50 of 69 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EYE-002 (10 mg/kg, i.p., 0.5-4 h post-administration, 2 h dark recovery after photobleach) restores 11cRAL and atREs levels to vehicle group levels at 4 h post-administration in BALB/cJ mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/cJ mice (6-8 weeks old, dark-adapted for 24 h)[1]
-
Dosage:10 mg/kg
-
Administration:i.p., 30 min pre-photobleach, 2 h dark recovery
-
Result:Reduced 11-cis-retinal (11cRAL) synthesis by 78%.
Increased all-trans-retinyl esters (atREs).
Recovered 80% of scotopic ERG a- and b-wave amplitudes at 8 h dark adaptation.
Reduced retinal autofluorescent puncta, preserves outer nuclear layer (ONL) thickness, and maintained scotopic ERG a- and b-wave amplitude.
-
Animal Model:BALB/cJ mice (6-8 weeks old, dark-adapted for 24 h)[1]
-
Dosage:10 mg/kg
-
Administration:i.p., 0.5-4 h post-administration, 2 h dark recovery after photobleach
-
Result:Restored 11cRAL and atREs levels to vehicle group levels at 4 h post-administration in BALB/cJ mice.
Chemical Information
-
Peso molecular 311.37
-
Fòrmula C16H25NO5
-
SMILES
O=CO.CCC(CC)C(OC1=CC=CC(C(O)CCN)=C1)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EYE-002 Related Classifications
HY-175663 Related Classifications
Powered by Bioz