FKGK11
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis.
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- No. CAS: 1071000-98-0
- Fòrmula: C13H13F5O
- Peso molecular:280.23
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
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PLA2 |
In Vitro
FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction[1].
FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA / mice and C57BL/6 mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1071000-98-0
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Appearance Liquid
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Peso molecular 280.23
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Fòrmula C13H13F5O
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Color Colorless to light yellow
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SMILES
O=C(C(F)(C(F)(F)F)F)CCCCC1=CC=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. [Content Brief]
[3]. López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FKGK11 Related Classifications
HY-116018 Related Classifications
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