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Referencia número: HY-112007

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Fluorosalan

Fluorosalan is an NF-κB inhibitor. Fluorosalan blocks the NF-κB signaling pathway by inhibiting the phosphorylation of IκBα. Fluorosalan induces depolarization of mitochondrial membrane potential in cancer cells and inhibits the growth of various cancer cells. Fluorosalan can be used in studies related to cervical cancer and rheumatoid arthritis.

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No. CAS: 4776-06-1
Fòrmula: C₁₄H₈Br₂F₃NO₂
Peso molecular:439.03

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fluorosalan Chemical Structure

No. CAS: 4776-06-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
ME-180	IC50	9.0 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation.	20067776
ME-180	IC50	2.7 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation.	20067776
ME-180	IC50	1.3 μM	Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation. Inhibition of cell viability in ME180 human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation.	20067776
HeLa	IC50	3.1 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 24 h incubation.	20067776
HeLa	IC50	2.1 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 48 h incubation.	20067776
HeLa	IC50	3.3 μM	Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation. Inhibition of cell viability in HeLa human cervical cancer cells assessed by CellTiter-Glo ATP quantitation assay after 72 h incubation.	20067776

In Vitro

Innate ImmunityCytokines & ChemokinesAnti-cancerApoptosisMitochondrial Function

Innate Immunity

Cytokines & Chemokines

Anti-cancer

Fluorosalan (5 pM-38 μM; 5 h) inhibits the transcriptional activity of NF-κB in TNF-α- and IL-1β-induced NF-κB-bla ME180 human cervical cancer cells, with IC₅₀ values of 7.9 μM and 24.4 μM, respectively^[1].

Innate Immunity

Cytokines & Chemokines

Fluorosalan (5 h) inhibits TNF-α-induced NF-κB transcriptional activity in NF-κB-luc2P HEK293 human embryonic kidney cells, with an IC₅₀ of 25.3 μM^[1].
Fluorosalan (30 min) inhibits TNF-α-induced phosphorylation of IκBα at serine-32 in GFP-IκBα GripTite HEK293 cells, with an IC₅₀ of 2.8 μM^[1].
Fluorosalan (10 μM; 1 h) reduces TNF-α-induced phosphorylation of IκBα at serine-32 in IkB HEK293 cells^[1].

Apoptosis

Fluorosalan (5-24 h) does not induce caspase 3/7 activity in NF-κB-bla ME180 human cervical cancer cells^[1].

Mitochondrial Function

Anti-cancer

Fluorosalan (24 h) depolarizes the mitochondrial membrane potential of ME180 human cervical cancer cells, with an IC₅₀ of 1.2 μM^[1].

Anti-cancer

Fluorosalan (5-72 h) inhibits the viability of ME180 human cervical cancer cells, with IC₅₀ values of 9.0 μM (24 h), 2.7 μM (48 h) and 1.3 μM (72 h)^[1].
Fluorosalan (5-72 h) inhibits the viability of human cervical cancer HeLa cells, with IC₅₀ values of 3.1 μM (24 h), 2.1 μM (48 h) and 3.3 μM (72 h)^[1].

Innate Immunity

Fluorosalan binds to the human IκBα/NF-κB complex (PDB ID: 1IKN) with a maximum binding energy of -8.5 kcal/mol, suggesting that it has potential inhibitory activity against the NF-κB signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

IkB HEK293 cells
Concentration:

10 μM
Incubation Time:

1 h
Result:

Reduced TNF-α-induced IκBα phosphorylation at serine-32.

Related Protocols :

Chemical Information

No. CAS 4776-06-1
Peso molecular 439.03
Fòrmula C₁₄H₈Br₂F₃NO₂
SMILES

O=C(NC1=CC=CC(=C1)C(F)(F)F)C=2C=C(Br)C=C(Br)C2O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Miller SC, et al. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical pharmacology. 2010 May 01;79(9):1272-80. [Content Brief]

[2]. Chakraborty D, et al. Potential role of Bavachin in Rheumatoid arthritis: Informatics approach for rational based selection of phytoestrogen[J]. Journal of Herbal Medicine, 2023, 38: 100640.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Fluorosalan

Actividad biológica

Descripciòn

Cellular Effect

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Fluorosalan Related Classifications

HY-112007 Related Classifications

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