G-25671
G-25671 is a platelet cyclooxygenase (COX) inhibitor (Ki = 4.5 μM) and uricosuric agent, as well as the active metabolite of Sulfinpyrazone (HY-B1271). G-25671 reduces the production of thromboxane B2 and malondialdehyde from arachidonic acid (AA), and inhibits human platelet aggregation induced by Sodium arachidonate (HY-109590A). G-25671 can be used in gout-related research.
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- No. CAS: 3736-92-3
- Fòrmula: C23H20N2O2S
- Peso molecular:388.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
G-25671 (2 min) potently inhibits Sodium arachidonate (HY-109590A)-induced aggregation in human platelet-rich plasma with a threshold inhibitory concentration of 26 μM, and is ~15 times more potent than sulfinpyrazone[1].
G-25671 (50 μM) inhibits cyclo-oxygenase-mediated metabolism of [14C]AA in washed human platelets, reducing TxB2 and HHT formation while increasing 12-HETE and unmetabolized AA levels[1].
G-25671 (5-40 μM) potently inhibits cyclo-oxygenase activity in human platelet-rich plasma, as measured by MDA generation, with a potency ~15 times higher than sulfinpyrazone, and shows parallel inhibition of MDA and TxB2 formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3736-92-3
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Peso molecular 388.49
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Fòrmula C23H20N2O2S
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SMILES
O=C1N(C=2C=CC=CC2)N(C=3C=CC=CC3)C(=O)C1CCSC=4C=CC=CC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Del Maschio A, et al. Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. European journal of pharmacology. 1984 Jun 01;101(3-4):209-14. [Content Brief]
[2]. Halder P, et al. PIDA-mediated N-N bond formation to access pyrazolidine-3,5-diones: a novel process for uricosuric agents G-25671 and sulfinpyrazone. Chemical communications (Cambridge, England). 2023 Jun 29;59(53):8242-8245. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G-25671 Related Classifications
HY-W551882 Related Classifications
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