TFF3 - trefoil factor 3 Gene

Also Known as ITF; P1B; TFI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7033

About TFF3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,311,667-42,315,409 (from NCBI)

This gene has 3 transcripts (splice variants), 92 orthologues and 2 paralogues. Biased expression in colon (RPKM 367.8), thyroid (RPKM 187.9) and 4 other tissues.

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two Other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF3 Products (1)

mRNA	Protein	Name
NM_003226.4	NP_003217.4	trefoil factor 3 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20423149	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20423149	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in extracellular region	IDA IDA: Inferred from direct assay	8454642	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFF3 Protein Structure

Trefoil

0
94 a.a.

Protein Preferred Names	Protein Names
trefoil factor 3	polypeptide P1.B

TFF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	TFF3	Q07654	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	TFF3	Q07654	FCGBP	Homo sapiens	Q9Y6R7	Comig Non-Denat Gel	31658587
Intra	TFF3	Q07654	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	TFF3	Q07654	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	TFF3	Q07654	PCBD1	Homo sapiens	P61457	Y2H Prey Pooling	25416956
Intra	TFF3	Q07654	PCBD1	Homo sapiens	P61457	Y2H Prey Pooling	32296183
Intra	TFF3	Q07654	TFF3	Homo sapiens	Q07654	Crosslink	20423149
Intra	TFF3	Q07654	TFF3	Homo sapiens	Q07654	GMS	31658587
Intra	TFF3	Q07654	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	TFF3	Q07654	PCBD1	Homo sapiens	P61457	Y2H Array	32296183
Intra	TFF3	Q07654	FCGBP	Homo sapiens	Q9Y6R7	Comig Non-Denat Gel	20423149

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TFF3 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P7295	TFF3 Protein, Human	Q07654 (E22-F80)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74529	TFF3 Protein, Human (HEK293, His)	Q07654 (E22-F80)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700523	TFF3 Protein, Human (P. pastoris, His)	Q07654 (A29-F80)	≥ 90%, as determined by reducing SDS-PAGE.

TFF3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81497	Trefoil Factor 3 Antibody (YA1242)	IHC-P	Human
HY-P81497A	Trefoil Factor 3 Antibody (YA1242)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Middle Cranial Fossa Meningioma	Meningioma Of The Middle Cranial Fossa
Neurilemmoma Of The Fifth Cranial Nerve	Trigeminal Schwannoma Trigeminal Neurilemmoma
Trigeminal Nerve Neoplasm	Neoplasm Of Trigeminal Nerve Tumor Of Trigeminal Nerve
Otosalpingitis	Eustachian Salpingitis Eustachian Tube Salpingitis Rhinosalpingitis Tubotympanitis Eustachian Tube Inflammation Salpingitis Of Ear
Viral Esophagitis
Eustachian Tube Disease	Eustachian Tube Disorder Auditory Tube Disorder Disease Of Eustachian Tube Eustachian Tube Dysfunction Et- [Eustachian Tube Disorder] Etd - [Eustachian Tube Dysfunction]
Medullary Colon Carcinoma
Non-Suppurative Otitis Media	Nonsuppurative Otitis Media
Colitis
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Alcoholic Psychosis	Psychoses, Alcoholic Alcoholic Psychoses
Malignant Otitis Externa	Necrotising Otitis Externa Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Enterocolitis
Inflammatory Bowel Disease 24	IBD24
Thyroid Cancer, Nonmedullary, 2	Thyroid Carcinoma, Follicular Follicular Thyroid Carcinoma NMTC2 Thyroid Cancer, Follicular Thyroid Carcinoma, Follicular, Somatic Ftc Thyroid Cancer, Non-Medullary, 2 Thyroid Follicular Carcinoma Follicular Thyroid Cancer Cancer, Thyroid, Nonmedullary, Type 2 Thyroid Gland Adenocarcinoma Follicular Carcinoma Of Unspecified Site Moderately Differentiated Follicular Carcinoma Of Thyroid Gland Pure Follicle Carcinoma Of Thyroid Gland Pure Follicle Follicular Carcinoma Of Unspecified Site Pure Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Thyroid Gland
Alcohol-Induced Mental Disorder	Psychoses, Alcoholic
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy	Epidermolysis Bullosa Simplex With Muscular Dystrophy Md-Ebs Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy EBS5B Ebsmd Mdebs Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex Ebs-Md Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy Epidermolysa Bullosa Simplex With Muscular Dystrophy Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy Ebs With Muscular Dystrophy Muscular Dystrophy With Epidermolysis Bullosa Simplex Epidermolysa Bullosa Simplex, With Muscular Dystrophy
Esophagus Adenocarcinoma	Esophageal Adenocarcinoma Oesophageal Adenocarcinoma Adenocarcinoma Of Esophagus Adenocarcinoma Of The Esophagus
Sphenoid Sinusitis	Sphenoidal Sinusitis
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Tremor, Hereditary Essential, 2	ETM2 Essential Tremor 2 Essential Tremor, Hereditary, 2 Hereditary Essential Tremor 2 Tremor Hereditary Essential, 2
Menkes Disease	Copper Transport Disease Menkes Syndrome MNK Kinky Hair Disease Steely Hair Disease Menkes Kinky-Hair Syndrome Mk Steely Hair Syndrome Menkea Syndrome Md Menkes Kinky Hair Syndrome Hypocupremia, Congenital Kinky Hair Syndrome X-Linked Copper Deficiency Menkes Kinky Hair Disease
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-139065	AMPC	Activator	99.11%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS14424	TFF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17594	Tff3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24054	Tff3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TFF3	VGNC	VGNC:35792
Macaca mulatta	TFF3	VGNC	VGNC:108447
Rattus norvegicus	TFF3	RGD	RGD:3847
Canis familiaris	TFF3	VGNC	VGNC:47298
Mus musculus	TFF3	MGD	MGI:104638
Felis catus	TFF3	VGNC	VGNC:66121
Others	TFF3	NCBI