C1QA - complement C1q A chain Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 712

About C1QA

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,636,463-22,639,678 (from NCBI)

This gene has 12 transcripts (splice variants), 171 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 445.5), lymph node (RPKM 179.4) and 16 other tissues.

Summary

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

C1QA Products (3)

mRNA	Protein	Name
NM_001347465.2	NP_001334394.1	complement C1q subcomponent subunit A precursor
NM_001347466.2	NP_001334395.1	complement C1q subcomponent subunit A precursor
NM_015991.4	NP_057075.1	complement C1q subcomponent subunit A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7240	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in complement activation, classical pathway	IDA IDA: Inferred from direct assay	29449492	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
part of complement component C1q complex	IPI IPI: Inferred from physical interaction	29449492	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18250442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QA Protein Structure

Collagen

C1q

0
100
200
245 a.a.

Protein Preferred Names	Protein Names
complement C1q subcomponent subunit A	complement C1q chain A

C1QA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	Far-WB	28018340
Intra	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	Solid Phase Assay	34804054
Intra	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	ELISA	28018340
Intra	C1QA	P02745	C1QB	Homo sapiens	P02746	Affinity Chrom	12960167
Intra	C1QA	P02745	C1QB	Homo sapiens	P02746	X-Ray Diffraction	12960167
Intra	C1QA	P02745	C1QB	Homo sapiens	P02746	ELISA	21054788
Intra	C1QA	P02745	C1QB	Homo sapiens	P02746	Enzymatic Footprint	7240
Intra	C1QA	P02745	C1QB	Homo sapiens	P02746	Filter Binding	28325905
Intra	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H	21988832
Intra	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

C1QA Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81468	C1QA Antibody (YA1213)	IHC-P	Human
HY-P81468A	C1QA Antibody (YA1213)(PBS only)	IHC-P	Human
HY-P83927	C1QA Antibody (YA3624)	IHC-P, FC, ELISA	Human
HY-P83927A	C1QA Antibody (YA3624)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
C1q Deficiency	C1QD Complement Component C1q Deficiency
Immunodeficiency Due To A Classical Component Pathway Complement Deficiency	Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency Immunodeficiency Due To An Early Component Of Complement Deficiency
Systemic Lupus Erythematosus 16	SLEB16 Autosomal Systemic Lupus Erythematosus Autosomal Sle Familial Sle Familial Systemic Lupus Erythematosus Lupus Erythematosus, Systemic, Type 16
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Glomerulonephritis	Bright'S Disease
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS01718	C1QA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18747	C1qa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25234	C1qa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	C1QA	VGNC	VGNC:60219
Canis familiaris	C1QA	VGNC	VGNC:38576
Mus musculus	C1QA	MGD	MGI:88223
Rattus norvegicus	C1QA	RGD	RGD:1306716
Bos taurus	C1QA	VGNC	VGNC:26616
Others	C1QA	NCBI