GSD-11
GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H28O2
- Peso molecular:300.44
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| PANC-1 | IC50 |
3.5 μM
Compound: GSD-11
|
Preferential cytotoxic activity against human PANC-1 cells in Dulbecco's modified Eagle's medium
Preferential cytotoxic activity against human PANC-1 cells in Dulbecco's modified Eagle's medium
|
[PMID: 34942553] |
GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC50 value of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PANC-1 cells
-
Concentration:0,1, 10, 100, 1000 µM
-
Incubation Time:
-
Result:Showed preferential cytotoxicity against PANC-1 cells with PC50 of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM).
-
Cell Line:PANC-1 cells
-
Concentration:2.5, 5, 10 µM
-
Incubation Time:
-
Result:Inhibited the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions.
Chemical Information
-
Peso molecular 300.44
-
Fòrmula C20H28O2
-
SMILES
[H][C@@]12CC[C@]3([C@@]4(CC(C([C@]4(CC[C@@]3([C@]1(CCC(C2)=O)C)[H])C)=C)=O)[H])[H]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSD-11 Related Classifications
HY-146738 Related Classifications
Powered by Bioz