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Referencia número: HY-45854

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GWP-042

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC₅₀ of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo.

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Pureza: 95.63%
No. CAS: 1645486-93-6
Fòrmula: C₁₄H₁₅FN₄O₂
Peso molecular:290.29

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GWP-042 Chemical Structure

No. CAS: 1645486-93-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC₅₀ of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo^[1].

Chemical Information

No. CAS 1645486-93-6
Appearance Solid
Peso molecular 290.29
Fòrmula C₁₄H₁₅FN₄O₂
Color White to off-white
SMILES

O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Nat Commun

Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. [Abstract]

2024 May 17;15(1):4216. PMID: 38760394
Research Square Preprint

2023 Sep 22.

Solvente y solubilidad

In Vitro:

H₂O : < 0.1 mg/mL (insoluble)

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15(1):4216.c [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

GWP-042

2 Cited Publications

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GWP-042

Publications Citing Use of MedChemExpress (MCE) GWP-042

Actividad biológica

Chemical Information

Publications (2)

Solvente y solubilidad

Pureza y Documentación

Referencias

Calculators

Help & FAQs

GWP-042 Related Classifications

HY-45854 Related Classifications