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Referencia número: HY-183859

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H142/08

H142/08 is a β1-adrenergic receptor-selective agonist. H142/08 induces concentration-dependent relaxation of isolated rat uterus and acts as a chronotropic stimulant to increase atrial rate, and its effects are effectively antagonized by Pafenolol (HY-165495). H142/08 also antagonizes the chronotropic effect of isoproterenol on isolated rat right atrium, but requires a higher proportion of receptor occupancy to produce sufficient stimulatory effects.

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No. CAS: 88017-05-4
Fòrmula: C₂₂H₃₇N₃O₆
Peso molecular:439.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

H142/08 Chemical Structure

No. CAS: 88017-05-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

Beta-1 adrenergic receptor

8.97 (pKd)

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In Vitro

H142/08 binds to β₁-adrenoceptors in guinea-pig left ventricular free wall membranes with a pK_d of 8.97^[1].
H142/08 binds to β₂-adrenoceptors in guinea-pig soleus muscle membranes with a pK_d of 5.88^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 88017-05-4
Peso molecular 439.55
Fòrmula C₂₂H₃₇N₃O₆
SMILES

O=C(N1CCOCC1)NCCNCC(COC2=CC=C(C=C2)OCCOCC(C)C)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Abrahamsson T, et al. Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70. Eur J Pharmacol. 1989;164(1):121-128. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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H142/08

Ver todos los productos específicos de isoformas Adrenergic Receptor

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H142/08 Related Classifications

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