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Referencia número: HY-187166

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Hamiformamide

Hamiformamide is a nitric oxide production inhibitor with an IC₅₀ of 49.1 μM, which is isolated from Hamigera avellanea IFM 52957. Hamiformamide inhibits nitric oxide production in macrophage-like cells. Hamiformamide modulates host immune signals.

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No. CAS: 179419-82-0
Fòrmula: C₁₉H₁₈N₂O₄
Peso molecular:338.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hamiformamide Chemical Structure

No. CAS: 179419-82-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas NO Synthase :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	IC₅₀	1.72 μM Compound: 4	Cytotoxicity against human A498 cells Cytotoxicity against human A498 cells	[PMID: 21667925]
ACHN	IC₅₀	1.37 μM Compound: 4	Cytotoxicity against human ACHN cells Cytotoxicity against human ACHN cells	[PMID: 21667925]
HOP-92	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human HOP92 cells Cytotoxicity against human HOP92 cells	[PMID: 21667925]
Malme-3M	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human MALME-3M cells Cytotoxicity against human MALME-3M cells	[PMID: 21667925]
MOLT-4	IC₅₀	1.81 μM Compound: 4	Cytotoxicity against human MOLT4 cells Cytotoxicity against human MOLT4 cells	[PMID: 21667925]
NCI-H460	IC₅₀	1.84 μM Compound: 4	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 21667925]
SF-295	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human SF295 cells Cytotoxicity against human SF295 cells	[PMID: 21667925]
SK-MEL-28	IC₅₀	2.03 μM Compound: 4	Cytotoxicity against human SK-MEL-28 cells Cytotoxicity against human SK-MEL-28 cells	[PMID: 21667925]
SK-MEL-5	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human SK-MEL-5 cells Cytotoxicity against human SK-MEL-5 cells	[PMID: 21667925]
SK-OV-3	IC₅₀	2.13 μM Compound: 4	Cytotoxicity against human SKOV3 cells Cytotoxicity against human SKOV3 cells	[PMID: 21667925]
U-251	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human U251 cells Cytotoxicity against human U251 cells	[PMID: 21667925]
UACC-62	IC₅₀	2.5 μM Compound: 4	Cytotoxicity against human UACC62 cells Cytotoxicity against human UACC62 cells	[PMID: 21667925]

In Vitro

Hamiformamide (5-100 μM; 2 h pre-incubation, 24 h incubation with LPS) potently inhibits LPS-induced nitric oxide production in RAW264 macrophage-like cells with an IC₅₀ of 49.1 µM while maintaining high cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 179419-82-0
Peso molecular 338.36
Fòrmula C₁₉H₁₈N₂O₄
SMILES

COC1=CC=C(/C=C(NC=O)/C(NC=O)=C/C2=CC=C(O)C=C2)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Saito S, et al. Activation of hamiformamide production in the thermotolerant fungus Hamigera avellanea triggered by co-culture with animal immune cells. J Antibiot (Tokyo). 2026 Jul 1. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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