HD-800
HD-800 is a tubulin inhibitor with an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. HD-800 can be used to generate a radioactive tracer [11C]HD-800, and [11C]HD-800 can penetrate the blood-brain barrier and be used for positron emission tomography (PET) in various neurological diseases.
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- No. CAS: 1204408-27-4
- Fòrmula: C15H15N3O2
- Peso molecular:269.30
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | GI50 |
10 nM
Compound: 3
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Cytotoxicity against human 786-0 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human 786-0 cells assessed as growth inhibition after 48 hrs by SRB assay
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[PMID: 27213719] |
Chemical Information
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No. CAS 1204408-27-4
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Peso molecular 269.30
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Fòrmula C15H15N3O2
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SMILES
N=1C=NC(=C2C1OC=C2C)N(C3=CC=C(OC)C=C3)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HD-800 Related Classifications
HY-180347 Related Classifications
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