HI042
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC50 values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML).
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- No. CAS: 898168-15-5
- Fòrmula: C14H11N3O3S
- Peso molecular:301.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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FLT3 |
HI042 shows IC50 values for MOLM-13 cells were 0.88, 0.52, and 0.36 μM and >40, 1.03, and 0.64 μM for MV4-11 cells for the periods of 24, 48, and 72 h, respectively[1].
HI042 (0.3-5 μM, 7-10 days) reduces autonomous clonal growth in MOLM-13 and MV4-11 cells[1].
HI042 (0.25-4 μM, 72 h) induces cell apoptosis and disrupts in MOLM-13 and MV4-11 cells[1].
HI042 (0.25-1 μM, 72 h) induces cell differentiation in MOLM-13 and MV4-11 cells[1].
HI042 (0.06-1 μM, 72 h) significantly reduces the viability companied with Quizartinib (HY-13001) (0.12-2 nM) in MOLM-13 and MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.312, 0.625, 1.25, 2.5, 5, 10, 20, and 40 μM
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Incubation Time:24, 48 and 72 h
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Result:Reduced cell viability in a time- and concentration dependent manner.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.25, 0.5 1, 2 and 4 μM
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Incubation Time:72 h
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Result:Increased the SubG1 cell population.
Increased PARP1 cleavage and γH2AX expression.
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Cell Line:MOLM-13 and MV4-11 cells
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Concentration:0.25, 0.5 and 1 μM
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Incubation Time:72 h
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Result:Increased CD11b-positive cells.
Increased expression of the genes CEBPA and CEBPB.
Chemical Information
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No. CAS 898168-15-5
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Peso molecular 301.32
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Fòrmula C14H11N3O3S
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SMILES
O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)/C=C/C2=CC=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HI042 Related Classifications
HY-175473 Related Classifications
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