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Referencia número: HY-183766

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HYF038

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with ¹¹C, HYF038 can be used for ASK1 neuroimaging studies.

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Fòrmula: C₁₇H₁₄F₄N₆O₂
Peso molecular:410.33

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

HYF038 Chemical Structure

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Actividad biológica

Descripciòn

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with ¹¹C, HYF038 can be used for ASK1 neuroimaging studies^[1].

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs) :

In Vivo

[¹¹C]HYF038 (0.04-0.4 mg/kg; intravenous injection via tail vein; single administration) exhibits a certain degree of BBB penetration, but shows low uptake; the high-dose blocking group presents a relatively high initial brain SUV followed by rapid washout^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male, 6 months old)^[1]
Dosage:

0.04 mg/kg; 0.4 mg/kg
Administration:

i.v.; single dose 5 minutes pre-[¹¹C]HYF038
Result:

Showed [¹¹C]HYF038 brain uptake similar to baseline animals at 0.04 mg/kg dose.
Revealed a blocking effect in the 0.04 mg/kg dose group via normalized brain time-activity curves.
Demonstrated an initial [¹¹C]HYF038 brain uptake peak SUV of 1.3 followed by rapid washout at 0.4 mg/kg dose.

Chemical Information

Peso molecular 410.33
Fòrmula C₁₇H₁₄F₄N₆O₂
SMILES

FC1=CN(C)C(C(C(NC2=NC(C3=NN=CN3[C@@H](C)C(F)(F)F)=CC=C2)=O)=C1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Huang Y, et al. The design, synthesis and evaluation of the first carbon-11 positron emission tomography radiotracer for ASK1 imaging. Bioorg Chem. 2026;178:109970. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HYF038

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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HYF038 Related Classifications

HY-183766 Related Classifications