iMAC2
iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release.
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- No. CAS: 335166-36-4
- Fòrmula: C19H20Br2FN3
- Peso molecular:469.19
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 28 nM (MAC)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.68 μM
Compound: 13
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In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
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[PMID: 14521400] |
In Vitro
iMAC2 (5 μM; pre-treatment for 1 hour and then treatment for 12 hours) reduces apoptosis in FL5.12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FL5.12 cells
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Concentration:5 μM
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Incubation Time:Pretreatment 1 h and then treatment with Staurosporine (HY-15141) for 12 hours
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Result:Reduced apoptosis by more than 50%.
Chemical Information
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No. CAS 335166-36-4
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Peso molecular 469.19
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Fòrmula C19H20Br2FN3
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SMILES
FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iMAC2 Related Classifications
HY-103272 Related Classifications
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