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Referencia número: HY-184153

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IMP-2958

IMP-2958 is an inactive enantiomeric negative control probe with significantly reduced binding to RAB27A/B-Cys123.IMP-2958 serves as a negative control probe for off-target binding in phenotypic assays related to RAB27A/B studies.IMP-2958 functions as a control for stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction.

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No. CAS: 3129691-65-9
Fòrmula: C₂₅H₂₆N₆O₅S
Peso molecular:522.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMP-2958 Chemical Structure

No. CAS: 3129691-65-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

In Vitro

IMP-2958 does not inhibit the WF pocket interaction of nRAB27A^Cys123, with an IC₅₀ > 100 μM in the FP competition assay^[1].
IMP-2958 (10 μM; 1 h) shows minimal covalent engagement of nRAB27A-Cys123, with only 7.7% labeling after 1-hour incubation at 10 μM^[1].
IMP-2958 (10 μM; 2 h) does not engage endogenous RAB27A or RAB27B in MDA-MB-231 cells at 10 μM, as it fails to compete with probe IMP-2566 for target binding^[1].
IMP-2958 (10-20 μM; 14 h) does not disrupt the RAB27A-SLP2-A protein-protein interaction in MDA-MB-231 cells at concentrations up to 20 μM after 14-hour incubation^[1].
IMP-2958 (10 μM; 24 h) does not phenocopy RAB27A knockout in melan-a mouse melanocytes at 10 μM after 24-hour incubation, as it does not induce perinuclear melanosome accumulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3129691-65-9
Peso molecular 522.58
Fòrmula C₂₅H₂₆N₆O₅S
SMILES

O=C([C@@H]1N(S(=O)(C2=CC=C(NC(C=C)=O)C=C2)=O)CCC1)NC3=CC=C(C(NC4=NN(C)C=C4)=O)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. De Vita E, et al. Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction. bioRxiv. 2026:2026-05.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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