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ISRIB

35 Cited Publications
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Based on 35 publication(s) in Google Scholar

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.

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  • Pureza: 99.0%
  • No. CAS: 548470-11-7
  • Fòrmula: C22H24Cl2N2O4
  • Peso molecular:451.34
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • ISRIB Chemical Structure
    ISRIB Chemical Structure
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
No. CAS: 548470-11-7
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Publications Citing Use of MedChemExpress (MCE) ISRIB

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WBHistological Imaging/StainingCell Proliferation/Viability AssayRT-PCR
  • Histological Imaging/Staining
  • RT-PCR
  • WB
  • Cell Proliferation/Viability Assay
  • WB
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  • ISRIB Chemical Structure
    ISRIB Chemical Structure
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    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905. [Abstract]

    Customer Validation
     Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. (B) Representative images of HE staining in liver sections after CCl4 treatment.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905. [Abstract]

    Customer Validation
     Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. Relative gene expression levels of ATF4 in liver tissues after CCl4 injection for 8 weeks (n = 4).

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35. [Abstract]

    Customer Validation
     Protein expression levels of ATF4, DDIT4, NIBAN1, p62, ATG5, and LC3-I/II were analyzed by Western blot in CAL 27 cells at 4 h after treatment with 1 mmol/L phenformin (Phen), 200 nmol/L ISRIB, or DMSO as a control.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35. [Abstract]

    Customer Validation
     CAL 27 cells were treated with 1 mmol/L phenformin (Phen) or with 200 nmol/L ISRIB or 1 μmol/L GSK2606414 or DMSO as a control. At 24 h, cells were collected and analyzed by the CCK-8 assay for cell viability.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: J Virol. 2018 Jul 31;92(16). pii: e00600-18. [Abstract]

    Customer Validation
     MARC-145 cells grown in six-well plates are treated with 0.5 mM Ars at 37°C for 1 h. The medium is changed to medium containing different concentrations of ISRIB and after 25 min, the cells are treated with puromycin, incubated at 37°C for 25 min, and lysed for western blotting analysis.

  • ISRIB