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Referencia número: HY-156399

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KR-27425

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE).

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No. CAS: 3047755-18-7
Fòrmula: C₁₀H₂₁N₃O₂
Peso molecular:215.29

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

KR-27425 Chemical Structure

No. CAS: 3047755-18-7

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Actividad biológica

Descripciòn

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE)^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
HFL1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
L929	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
NIH3T3	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
Vero	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]

Chemical Information

No. CAS 3047755-18-7
Peso molecular 215.29
Fòrmula C₁₀H₂₁N₃O₂
SMILES

CC(CCCNCCNC(/C=N/O)=O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Vishakantegowda AG, et al. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129504. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KR-27425

Ver todos los productos específicos de isoformas Endogenous Metabolite

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KR-27425 Related Classifications

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