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Referencia número: HY-P3970

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KRFK

4 Cited Publications

Revisión del cliente

Based on 4 publication(s) in Google Scholar

KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach.

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No. CAS: 162290-78-0
Fòrmula: C₂₇H₄₇N₉O₅
Peso molecular:577.72

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Please store the product under the recommended conditions in the Certificate of Analysis.

KRFK Chemical Structure

No. CAS: 162290-78-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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Actividad biológica

Descripciòn

IC₅₀ & Target

TGF-β^[1]

Ver todos los productos específicos de isoformas TGF-β Receptor :

In Vitro

KRFK (50 μM; 24 h) activates the secretion of TGF-β and reduces the expression of DC maturation markers in tsp-1 deficient bone marrow-derived dendritic cells (BMDCs) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KRFK (5 μg/5 μL/eyes; single dose) significantly prevents the development of chronic ocular surface inflammation in TSP-1^-/- mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 162290-78-0
Peso molecular 577.72
Fòrmula C₂₇H₄₇N₉O₅
Sequence

Lys-Arg-Phe-Lys
Sequence Shortening

KRFK
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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JCI Insight

Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling. [Abstract]

2024 May 8;9(9):e168792. PMID: 38716730
Molecules

Involucrasin B Inhibits the Proliferation of Caco-2 Cells by Regulating the TGFβ/SMAD2-3-4 Pathway. [Abstract]

2024 Feb 1;29(3):686. PMID: 38338430
Curr Eye Res

Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment. [Abstract]

2025 Jun 24:1-9. PMID: 40555256
bioRxiv

2025 Sep 21.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Soriano-Romaní L, et al. Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20;20(1):9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KRFK

4 Cited Publications

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KRFK

Publications Citing Use of MedChemExpress (MCE) KRFK

Ver todos los productos específicos de isoformas TGF-β Receptor

Actividad biológica

Chemical Information

Publications (4)

Pureza y Documentación

Referencias

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KRFK Related Classifications

HY-P3970 Related Classifications