Lamiide
Based on 1 Customer Validation
Lamiide, an orally active iridoid compound, can be found in Bouchea fluminensis leaves. Lamiide exhibits anti-inflammatory and anti-lipoperoxidative activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.0%
- No. CAS: 27856-54-8
- Fòrmula: C17H26O12
- Peso molecular:422.38
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Lamiide inhibits rat-brain phospholipid peroxidation, with an IC50 of 0.92 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Wistar rats (8-weeks old, 150-200 g) were injected with Carrageenin in the subplantar aponeurosis of the right hind paw[1]
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Dosage:12.5, 25, 50, 100 mg/kg
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Administration:P.o. 30 min before Carrageenin injection
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Result:Reduced Carrageenin-induced edema, with an ED50 of 62.3 mg/kg.
Chemical Information
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No. CAS 27856-54-8
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Appearance Solid
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Peso molecular 422.38
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Fòrmula C17H26O12
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Color White to off-white
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SMILES
O[C@]12[C@]([C@@](O)([C@H](C2)O)C)([H])[C@@H](OC=C1C(OC)=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lamiide Related Classifications
HY-N3408 Related Classifications
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