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Referencia número: HY-123639

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LM-4108

(Synonyms: N-(2-Phenylethyl)-indomethacin amide)

LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC₅₀ of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively.

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No. CAS: 261766-32-9
Fòrmula: C₂₇H₂₅ClN₂O₃
Peso molecular:460.95

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (271 KB)

LM-4108 Chemical Structure

No. CAS: 261766-32-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Human COX-2

60 nM (IC₅₀)

Ovine COX-1

>66 μM (IC₅₀)

Ver todos los productos específicos de isoformas COX :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	0.21 μM Compound: LM-4108	Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay Inhibition of COX2 in mouse RAW264.7 cells by enzyme immunoassay	[PMID: 20056549]
RAW264.7	IC₅₀	56.7 μM Compound: LM-4108	Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassay	[PMID: 20056549]

Chemical Information

No. CAS 261766-32-9
Appearance Solid
Peso molecular 460.95
Fòrmula C₂₇H₂₅ClN₂O₃
Color White to off-white
SMILES

O=C(N1C2=C(C(CC(NCCC3=CC=CC=C3)=O)=C1C)C=C(OC)C=C2)C4=CC=C(C=C4)Cl
Synonyms

N-(2-Phenylethyl)-indomethacin amide
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. [Content Brief]

[2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122.

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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LM-4108

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas COX

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

LM-4108 Related Classifications

HY-123639 Related Classifications