Lu AA33810
Based on 1 Customer Validation
Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.
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- Pureza: 98.3%
- No. CAS: 304008-29-5
- Fòrmula: C19H25N3O2S3
- Peso molecular:423.62
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Ver todos los productos específicos de isoformas Neuropeptide Y Receptor
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Actividad biológica
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hY5 receptor 1.5 nM (Ki) |
Lu AA33810 antagonizes NPY-evoked cAMP and calcium mobilization in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Flinders sensitive line rats, chronic dosing of Lu AA33810 (10 mg/kg/day i.p.) produces anxiolytic-like effects in the social interaction test, plus antidepressant-like effects in the forced swim test[1].
In Wistar rats exposed to chronic mild stress, chronic dosing of Lu AA33810 (3 and 10 mg/kg/day i.p.) produces antidepressant-like activity, i.e., normalization of stress-induced decrease in sucrose consumption[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 304008-29-5
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Appearance Solid
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Peso molecular 423.62
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Fòrmula C19H25N3O2S3
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Color White to off-white
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SMILES
CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 42.36 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11. [Content Brief]
[2]. Domin H,et al. Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology (Berl). 2017 Feb;234(4):631-645. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3606 mL | 11.8030 mL | 23.6061 mL | 59.0152 mL |
| 5 mM | 0.4721 mL | 2.3606 mL | 4.7212 mL | 11.8030 mL | |
| 10 mM | 0.2361 mL | 1.1803 mL | 2.3606 mL | 5.9015 mL | |
| 15 mM | 0.1574 mL | 0.7869 mL | 1.5737 mL | 3.9343 mL | |
| 20 mM | 0.1180 mL | 0.5902 mL | 1.1803 mL | 2.9508 mL | |
| 25 mM | 0.0944 mL | 0.4721 mL | 0.9442 mL | 2.3606 mL | |
| 30 mM | 0.0787 mL | 0.3934 mL | 0.7869 mL | 1.9672 mL | |
| 40 mM | 0.0590 mL | 0.2951 mL | 0.5902 mL | 1.4754 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 1.1803 mL | |
| 60 mM | 0.0393 mL | 0.1967 mL | 0.3934 mL | 0.9836 mL | |
| 80 mM | 0.0295 mL | 0.1475 mL | 0.2951 mL | 0.7377 mL |
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