MG-Lin2
MG-Lin2 is a Lin28 molecular glue degrader. It induces the formation of a ternary complex between Lin28 and the E3 ubiquitin ligase RNF126, mediates the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the abundance and function of mature let-7 miRNA. MG-Lin2 can be used in studies of ovarian cancer and choriocarcinoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C29H27F3N6O2
- Peso molecular:548.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
MG-Lin2 (0.1-100 μM; 24 h) showed
a proper dose-response relationship, with a significant reduction in luciferase intensity at 0.1 μM.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Peso molecular 548.56
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Fòrmula C29H27F3N6O2
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SMILES
CC1=NN=C2C=CC(C3=CC=CC(N(C(C4CCN(CC4)C(/C=C/C5=CC=C(C=C5)C(F)(F)F)=O)=O)C)=C3)=NN12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MG-Lin2 Related Classifications
HY-177732 Related Classifications
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