Milbemycin A3
Based on 1 Customer Validation
Milbemycin A3 is a 16-membered macrocyclic lactone compound found in the soil bacterium Saccharopolyspora hygroscopicus subsp. aureolacrimosus. Milbemycin A3 enhances the opening of glutamate- and GABA-gated chloride channels and exhibits insecticidal activity. Milbemycin A3 can be used in insect resistance-related research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.46%
- No. CAS: 51596-10-2
- Fòrmula: C31H44O7
- Peso molecular:528.68
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-126906
Milbemycin A4P-gp Inhibitor -
HY-130423R
Milbemycin A3 (Standard)Insecticide -
HY-15308
Avermectin B1aAntibiotic -
HY-18982
AnisomycinProtein Synthesis Inhibitor -
HY-B0767
Spinosyn AInsecticide -
HY-N7071A
Maduramicin ammoniumAntibiotic -
HY-126906R
Milbemycin A4 (Standard)P-gp Inhibitor -
HY-18982R
Anisomycin (Standard)Protein Synthesis Inhibitor -
HY-B1864A
Kasugamycin hydrochlorideAntibiotic -
HY-15308R
Avermectin B1a (Standard)Antibiotic -
HY-125326
Spinosyn DSpinosad Component -
HY-N7071AR
Maduramicin ammonium (Standard)Anticoccidial Agent
Actividad biológica
Descripciòn
In Vitro
Milbemycin A3 shows potent acaricidal and nematocidal activities as the major active component of the milbemycin A3/A4 mixture[1].
Milbemycin A3 (8 days) is eliminated of C5-O-methylated milbemycin byproducts and shows an increased yield of milbemycin A3/A4 to 2237 μg/mL in Streptomyces bingchenggensis BCJ13 with deleted milD gene; meanwhile, in strain BCJ36 with combined deletion of milD and nanLD genes, Milbemycin A3 is eliminated of both C5-O-methylated milbemycin byproducts and nanchangmycin[3].
Milbemycin A3, when analyzed in Streptomyces bingchenggensis BCJ36 (five successive subcultivations; 8 days per fermentation), shows genetic stability, maintaining elimination of unwanted byproducts[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 51596-10-2
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Appearance Solid
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Peso molecular 528.68
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Fòrmula C31H44O7
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Color White to light yellow
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SMILES
C[C@H]1CC[C@@]2(O[C@@H]1C)C[C@@H]3C[C@@H](C/C=C(C)/C[C@@H](C)/C=C/C=C4CO[C@H]5[C@]\4(O)[C@H](C(O3)=O)C=C(C)[C@H]5O)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 33.33 mg/mL (63.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Yang LY, et al. New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3. Bioorg Med Chem Lett. 2013;23(20):5710-5713. [Content Brief]
[2]. Nakagawa K, et al. Microbial conversion of milbemycins: hydroxylation of milbemycin A4 and related compounds by Cunninghamella echinulata ATCC 9244. J Antibiot (Tokyo). 1991;44(2):232-240. [Content Brief]
[3]. Zhang J, et al. Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin. Appl Microbiol Biotechnol. 2013;97(23):10091-10101. [Content Brief]
[4]. Duke SO, et al. Natural toxins for use in pest management. Toxins (Basel). 2010;2(8):1943-1962. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8915 mL | 9.4575 mL | 18.9150 mL | 47.2876 mL |
| 5 mM | 0.3783 mL | 1.8915 mL | 3.7830 mL | 9.4575 mL | |
| 10 mM | 0.1892 mL | 0.9458 mL | 1.8915 mL | 4.7288 mL | |
| 15 mM | 0.1261 mL | 0.6305 mL | 1.2610 mL | 3.1525 mL | |
| 20 mM | 0.0946 mL | 0.4729 mL | 0.9458 mL | 2.3644 mL | |
| 25 mM | 0.0757 mL | 0.3783 mL | 0.7566 mL | 1.8915 mL | |
| 30 mM | 0.0631 mL | 0.3153 mL | 0.6305 mL | 1.5763 mL | |
| 40 mM | 0.0473 mL | 0.2364 mL | 0.4729 mL | 1.1822 mL | |
| 50 mM | 0.0378 mL | 0.1892 mL | 0.3783 mL | 0.9458 mL | |
| 60 mM | 0.0315 mL | 0.1576 mL | 0.3153 mL | 0.7881 mL |
Milbemycin A3 Related Classifications
HY-130423 Related Classifications
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