Mitobronitol
Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia.
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- No. CAS: 488-41-5
- Fòrmula: C6H12Br2O4
- Peso molecular:307.97
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (8-10 weeks old)[2]
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Dosage:850 mg/kg; 1500 mg/kg (suspended in 5% Tween 80 in saline, 0.5 mL)
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Administration:Intraperitoneal injection; single dose
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Result:Showed effect on the in vitro proliferative response of spleen cells to mitogens at 850 mg/kg.
Enhanced thymus regeneration and was earlier than control, with the starting resititution time-course of 2 weeks and subtotal resititution time course of 3 weeks under 1500 mg/kg dose.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 488-41-5
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Appearance Solid
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Peso molecular 307.97
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Fòrmula C6H12Br2O4
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Color White to off-white
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SMILES
O[C@@H]([C@H]([C@@H]([C@@H](CBr)O)O)O)CBr
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Synonyms
Myelobromol; DBM
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Silver RT, et al. A comparative study of dibromomannitol and busulfan in the treatment of chronic myeloid leukemia. A study of cancer and leukemia group B. Cancer. 1987 Oct 1;60(7):1442-8. [Content Brief]
[2]. Szebeni J, et al. Comparison of the lymphoid toxicities of mitobronitol and busulphan in mice: reduced B cell toxicity and improved thymic recovery as possible contributors to the reduced risk for complications following BMT with mitobronitol preconditioning. Leukemia. 1997 Oct;11(10):1769-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mitobronitol Related Classifications
HY-13641 Related Classifications
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