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Referencia número: HY-14404

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MK-1220

MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a K_i of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC₅₀s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection.

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No. CAS: 924270-31-5
Fòrmula: C₄₀H₅₃N₅O₉S
Peso molecular:779.94

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MK-1220 Chemical Structure

No. CAS: 924270-31-5

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	11 nM Compound: 15j, MK-1220	Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum	[PMID: 24900304]
Huh-7	IC₅₀	11 nM Compound: 2	Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS	[PMID: 24900473]
Huh-7	IC₅₀	4 nM Compound: 15j, MK-1220	Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum	[PMID: 24900304]
Huh-7	IC₅₀	5 nM Compound: 15j, MK-1220	Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum	[PMID: 24900304]

Chemical Information

No. CAS 924270-31-5
Peso molecular 779.94
Fòrmula C₄₀H₅₃N₅O₉S
SMILES

CC(C)(COC(N[C@@H](C1CCCCC1)C(N2[C@H](C(N[C@@](C3)(C(NS(=O)(C4CC4)=O)=O)[C@@H]3C=C)=O)C[C@@H](O5)C2)=O)=O)CCCC6=C(OC)C=C7C(C5=NC=C7)=C6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Rudd MT, et al. Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure. ACS Med Chem Lett. 2011 Jan 12;2(3):207-12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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