ML-133
Based on 3 publication(s) in Google Scholar
ML133 is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
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- No. CAS: 185669-79-8
- Fòrmula: C19H19NO
- Peso molecular:277.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) ML-133
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Actividad biológica
IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.8 μM
Compound: 162, ML133
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Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique
Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique
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[PMID: 23121096] |
Chemical Information
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No. CAS 185669-79-8
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Peso molecular 277.36
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Fòrmula C19H19NO
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SMILES
COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Metab
2022 Nov 1;34(11):1843-1859.e11. PMID: 36103895 -
Pharmacol Res
Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection. [Abstract]2022 Feb 2;177:106112. PMID: 35122955 -
Cell Death Dis
Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells. [Abstract]2026 Jun 16. PMID: 42303628
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)