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Referencia número: HY-162967

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MS8588

MS8588 is a deubiquitinase-targeting chimera (DUBTAC) against cGAS. MS8588 induces targeted stabilization of cGAS, thereby activating downstream signaling pathways. MS8588 activates the cGAS/STING/IRF3 innate immune signaling pathway. MS8588 exhibits antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3060519-94-7
Fòrmula: C₄₅H₅₉Cl₂N₉O₆S
Peso molecular:924.98

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MS8588 Chemical Structure

No. CAS: 3060519-94-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

MS8588 (0-10 μM; 0-24 h) stabilizes cGAS and activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in a concentration-, time-, cGAS- and OTUB1-dependent manner, without altering the expression level of cGAS mRNA; its stabilizing effect on cGAS reaches a peak when acting at 5 μM for 24 h^[1].
MS8588 (5 μM; 2-14 days) effectively inhibits the proliferation and colony-forming ability of HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HeLa cells
Concentration:

5 μM
Incubation Time:

2 days (proliferation assay); 2 weeks (clonogenicity assay)
Result:

Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.

Chemical Information

No. CAS 3060519-94-7
Peso molecular 924.98
Fòrmula C₄₅H₅₉Cl₂N₉O₆S
SMILES

ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CCNC(CCCCCCCCCC(NCCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Deng Z, et al. The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS. Angew Chem Int Ed Engl. 2025;64(3):e202415168. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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