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Referencia número: HY-14128

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NBI-34041

(Synonyms: SB-723620)

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC₅₀ of 58.9 nM and a K_i of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 268545-87-5
Fòrmula: C₂₂H₂₆Cl₂N₄
Peso molecular:417.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NBI-34041 Chemical Structure

No. CAS: 268545-87-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

CRFR1

58.9 nM (IC₅₀)

CRFR1

4 nM (Ki)

CRFR2

>10000 nM (IC₅₀)

Ver todos los productos específicos de isoformas CRFR :

CRFR1
CRFR2

In Vitro

NBI-34041 could inhibit the production of cAMP in a concentration-dependent manner with an IC₅₀ of approximately 60 nM. At concentrations of NBI-34041 up to 10 000 nM, NBI-34041 is unable to fully inhibit sauvagine stimulated cAMP from cells expressing the human CRF2 receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NBI-34041 (3-30 mg/kg; oral gavage; a single dose) significantly attenuates the elevation in plasma ACTH induced by CRF. NBI-34041 also demonstrates efficacy in attenuating shock-induced ACTH release in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar or Sprague-Dawley rats (300-350 g)^[1]
Dosage:

3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration:

Oral gavage; a single dose
Result:

Did not impair diurnal adrenocorticotropic hormone (ACTH) and cortisol secretion or CRF evoked ACTH and cortisol responses but attenuated the neuroendocrine response to psychosocial stress.

Chemical Information

No. CAS 268545-87-5
Peso molecular 417.37
Fòrmula C₂₂H₂₆Cl₂N₄
SMILES

CC1=NC2=C3C(N(C(CCC)CCC)CCN3N=C2C4=CC=C(Cl)C=C4Cl)=C1
Synonyms

SB-723620
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Marcus Ising, et al. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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NBI-34041

Ver todos los productos específicos de isoformas CRFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

NBI-34041 Related Classifications

HY-14128 Related Classifications