Nirsevimab
Based on 2 publication(s) in Google Scholar
Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.63%
- No. CAS: 1989556-22-0
- Peso molecular:146.31 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Nirsevimab
More
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
Actividad biológica
Human IgG1 kappa
Human
RSV-F
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-week-old female BALB/c mice[2].
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Dosage:10 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
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Administration:Intramuscular injection (i.m.); administer medication 24 hours prior to RSV virus exposure
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Result:Inhibited the secretion of sIgA, mucosal IgA, and mucosal IgG in the offspring subsequent to the initial RSV infection.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
A0A0X8XRK2
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Fusion glycoprotein F0/F Protein, HRSV (sf9, His, HY-P75182) can bind Nirsevimab. The EC50 for this effect is 44 ng/mL.
Chemical Information
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No. CAS 1989556-22-0
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Appearance Liquid
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Peso molecular 146.31 kDa
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Color Colorless to light yellow
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SMILES
[Nirsevimab]
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Synonyms
MEDI8897
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Med Virol
Development of a HEp2-CDX Mouse Model With Sustained High RSV Viral Loads for Robust Antiviral Therapeutic Evaluation. [Abstract]2025 Sep;97(9):e70601. PMID: 40947663 -
Nirsevimab purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Feb 4.
All MARMs could be rescued by at least one other mAb. Three RSM01 MARMs (RSM-1 to RSM-3) could still be neutralised by nirsevimab and clesrovimab.
Nirsevimab purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Feb 4.
RSV-B isolates displayed 17 highly variable positions, two of which are located in overlapping RSM01/nirsevimab binding sites.
Pureza y Documentación
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Ficha de datos (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Brady T, et al. Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection. Front Immunol. 2023 Oct 11;14:1283120. [Content Brief]
[2]. Ma J, et. Exacerbated lung inflammation in offspring with high maternal antibody levels following secondary RSV exposure. Front Immunol. 2024 Apr 30;15:1377374. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nirsevimab Related Classifications
HY-P99756 Related Classifications
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