NPD15261

NPD15261 (0-10 μM; 2 h) inhibits basal and HGF-induced phosphorylation of MET at Y1234/Y1235 in JHH7 cells with an IC₅₀ of 0.77 μM, and also suppresses HGF-induced MET phosphorylation at Y1349^[1].
NPD15261 (0-10 μM) dose-dependently inhibits the expression of MYCN mRNA and protein in JHH7 cells, and this effect can be partially reversed by stimulation with 20 ng/mL HGF^[1].
NPD15261 (0-5 μM; 4 days) selectively reduces the viability of JHH7 cells and the survival rate of JHH7 spheroids at the concentration of 5 μM, with no effect on normal Hc cells^[1].
NPD15261 (2.5-10 μM; 0-12 days) inhibits colony formation of JHH7 cells and exerts a dose-dependent inhibitory effect on the proliferation of JHH7 cells^[1].
NPD15261 (2.5 μM; 24 h) induces apoptosis in JHH7 cells, while exhibiting extremely low cytotoxicity against normal Hc cells^[1].
NPD15261 (5-10 μM; 6 h) downregulates MYCN-related oncogenic pathways (including MYC_Targets_V2, MYC_Targets_V1 and E2F_Targets), and selectively inhibits MYCN target genes in JHH7 cells after 6 hours of treatment, with no effect on normal Hc cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.