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Referencia número: HY-118542

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Nutlin 1

Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC₅₀ value of 0.26 μM.

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No. CAS: 548472-58-8
Fòrmula: C₃₂H₃₄Cl₂N₄O₄
Peso molecular:609.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Nutlin 1 Chemical Structure

No. CAS: 548472-58-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC₅₀ value of 0.26 μM^[1].

Chemical Information

No. CAS 548472-58-8
Peso molecular 609.54
Fòrmula C₃₂H₃₄Cl₂N₄O₄
SMILES

CC(N1CCN(CC1)C(N2[C@H]([C@H](N=C2C3=CC=C(C=C3OC(C)C)OC)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Lyubomir T Vassilev, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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