OAT-2068
OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC50=29 nM) and displays 143-fold selectivity over m AMCase (IC50=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.
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- No. CAS: 2221950-65-6
- Fòrmula: C23H36ClN7
- Peso molecular:446.03
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 29 nM (mCHIT1); 4200 nM (mAMCase)IC50: 67 nM (hCHIT1); 1300 nM (hAMCase)[2]
In Vitro
OAT-2068 is a potent inhibitor developed for mAMCase (IC50=4200 nM) and mCHIT1(IC50=29 nM), which also displays activity toward hAMCase (IC50=67 nM) and hCHIT1 (IC50=1300 nM), it exhibits off-target activity toward the human ether-a-go-go-related gene (hERG)(hERG IC50=2.4 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2221950-65-6
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Peso molecular 446.03
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Fòrmula C23H36ClN7
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SMILES
NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28(3):310-314. [Content Brief]
[2]. Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OAT-2068 Related Classifications
HY-125279 Related Classifications
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