OX01914
OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).
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- No. CAS: 49676-35-9
- Fòrmula: C17H14N4O
- Peso molecular:290.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
OX01914 (0.1, 10, 40, 50 μM; 24 h) upregulates utrophin mRNA in LUmdx and (30 μM; 24 h) H2K mdx myoblasts[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:LUmdx and H2K mdx myoblasts
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Concentration:0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
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Incubation Time:24 h
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Result:Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.
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Cell Line:Human DMD cells
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Concentration:1, 3, 30 µM
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Incubation Time:24 h
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Result:Increased utrophin protein levels by approximately 3-fold.
Chemical Information
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No. CAS 49676-35-9
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Peso molecular 290.32
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Fòrmula C17H14N4O
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SMILES
O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OX01914 Related Classifications
HY-150078 Related Classifications
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