Pabulenol
Pabulenol is a linear furanocoumarin derivative with anti-proliferative, cytotoxic and anti-platelet aggregation activities. Pabulenol inhibits the proliferation of lymphoma cells and platelet aggregation. Pabulenol can be used in relevant studies on T-cell lymphoma, hypertension and thrombotic diseases such as atherosclerosis.
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- No. CAS: 33889-70-2
- Fòrmula: C16H14O5
- Peso molecular:286.28
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Pabulenol (72 h) inhibits proliferation of L5178Y PAR and L5178Y MDR mouse T-cell lymphoma cells with IC50 values of 30.47 μM and 29.28 μM, respectively, after 72 h of incubation[1].
Pabulenol (24 h) induces cytotoxicity in L5178Y PAR mouse T-cell lymphoma cells and NIH/3T3 mouse embryonic fibroblast cells with IC50 values of 51.32 μM and 54.09 μM, respectively[1].
Pabulenol (2-20 μM; 10 min) does not inhibit the ABCB1 efflux pump in L5178Y MDR mouse T-cell lymphoma cells, as shown by FAR values of 0.82 and 0.75, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 33889-70-2
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Peso molecular 286.28
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Fòrmula C16H14O5
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SMILES
O(C[C@H](C(C)=C)O)C=1C2=C(C=C3C1C=CO3)OC(=O)C=C2
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Mottaghipisheh J, et al.. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia. Pharmaceutical biology. 2018 Dec;56(1):658-664. [Content Brief]
[2]. Lee YY, et al.. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of pharmacal research. 2003 Sep;26(9):723-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pabulenol Related Classifications
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